Always inform your doctor about all medications you’re taking, including over-the-counter drugs, supplements, and herbal remedies, before starting Tadalafil. This includes nitrates, commonly used to treat chest pain (angina). Combining Tadalafil with nitrates can cause a dangerous drop in blood pressure.
Alpha-blockers, prescribed for high blood pressure or prostate problems, can also interact with Tadalafil. Concurrent use may significantly lower blood pressure, potentially leading to dizziness or fainting. Your doctor might adjust your dosage or recommend an alternative.
Certain antifungal medications (like ketoconazole and itraconazole) and HIV protease inhibitors can increase Tadalafil levels in your blood, potentially intensifying side effects. Your doctor may suggest a lower Tadalafil dose.
Grapefruit juice inhibits the enzymes that metabolize Tadalafil, leading to higher blood levels. Avoid grapefruit juice while taking Tadalafil.
Alcohol can enhance Tadalafil’s side effects, particularly dizziness and lightheadedness. Moderate your alcohol intake or avoid it altogether.
| Nitrates | Severe drop in blood pressure | Avoid concurrent use. |
| Alpha-blockers | Significant blood pressure reduction | Dosage adjustment may be necessary. |
| Antifungal medications (ketoconazole, itraconazole) | Increased Tadalafil blood levels | Lower Tadalafil dose may be recommended. |
| HIV protease inhibitors | Increased Tadalafil blood levels | Lower Tadalafil dose may be recommended. |
| Grapefruit juice | Increased Tadalafil blood levels | Avoid consumption. |
| Alcohol | Enhanced side effects | Moderate or avoid alcohol consumption. |
This information is not exhaustive. Consult your doctor or pharmacist for a complete list of potential interactions and personalized advice.
